Adaptive Pharmacogenomics, LLC

Using a new, powerful method for rapidly screening molecules associated with disease, proteomics expert Joshua LaBaer and colleagues from the Biodesign Institute at Arizona State University have identified a broad panel of 28 early predictors, or biomarkers, that may one day aid in the early diagnosis of breast cancer.

( from http://www. rxpgnews. com ) (Boston)- Researchers from Boston University School of Medicine (BUSM) have been awarded a five-year, $2 million grant from the National Cancer Institute (NCI) Early Detection Research Network (EDRN), as well as a four-year, $1. 3 million grant from the Department of Defense (DOD).

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Pharmacogenetics Human

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PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals.

( from http://www. rxpgnews. com ) Bone health experts attending the 1st Asia-Pacific Osteoporosis Meeting in Singapore this week have flagged vitamin D deficiency as a major concern in the region, particularly in South Asia where the problem is especially severe and widespread across the entire population.

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Cancer prevention experts have long been frustrated by the lack of a meaningful way to screen women for ovarian cancer. It is a relatively rare disease that often progresses with few symptoms until it is too late for potentially curative treatments, and elevated values of the most commonly used biomarker used in screening, CA125, are also related to other disorders.

Mayo Clinic researchers found that the part of the brain generating seizures in individuals with epilepsy is functionally isolated from surrounding brain regions. The researchers hope this finding could be a clinical biomarker to help identify individuals with abnormal brain function. This study was presented at the American Epilepsy Society's annual meeting in San Antonio on Dec. 4.

With the use of a highly sensitive test, detection of the blood biomarker cardiac troponin T, a cardiac-specific protein, is associated with structural heart disease and an increased risk of all-cause death, according to a study in the Dec. 8 issue of JAMA.

Personalized medicine centers on being able to predict the risk of disease or response to a drug based on a person's genetic makeup. But a new study suggests that, for most common diseases, genes alone only tell part of the story. Their research shows the environment interacts with DNA in ways that are difficult to predict, even in simple organisms like single-celled yeast.

Gene Polymorphisms

Bull Cancer. 2010 Nov 1;97(11):1253-1264

Authors: Robert J

Cancers can be considered as gene diseases. A number of mechanisms leading to cancer have been identified through the discovery of structural alterations of genes called 'oncogenes' and 'tumour suppressor genes'.

In two papers published on Dec. 2 in the open-access scientific journal PLoS One, researchers at SomaLogic Inc. and their collaborators describe a revolutionary new approach to biomarker detection and demonstrate its potential diagnostic power in a large-scale study that identifies a panel of biomarkers that can detect lung cancer in its early -- and treatable -- stages.