Establishing clinical utility of pharmacogenetic tests in the post-FDAAA era.
Clin Pharmacol Ther. 2010 Dec;88(6):749-51
Authors: Evans BJ
The US Food and Drug Administration (FDA) Amendments Act of 2007, when fully implemented, will offer new sources of evidence and new regulatory mechanisms during the postmarket phase of drug life.
Opioid pharmacogenomics using a twin study paradigm: methods and procedures for determining familial aggregation and heritability.
Twin Res Hum Genet. 2010 Oct;13(5):412-25
Authors: Angst MS, Phillips NG, Drover DR, Tingle M, Galinkin JL, Christians U, Swan GE, Lazzeroni LC, Clark JD
Opioids are the cornerstone medication for the treatment of moderate to severe pain.
Acceptance of biomarker-based tests for application in clinical practice: criteria and obstacles.
Clin Pharmacol Ther. 2010 Dec;88(6):862-6
Authors: Pirmohamed M
The journey from the discovery of a biomarker to its implementation in clinical practice is long and complex.
Cancer pharmacogenomics and pharmacoepidemiology: setting a research agenda to accelerate translation.
J Natl Cancer Inst.
Maternal-fetal and neonatal pharmacogenomics: a review of current literature.
J Perinatol.
The role of CYP2D6 and ABCB1 pharmacogenetics in drug-naïve patients with first-episode schizophrenia treated with risperidone.
Eur J Clin Pharmacol. 2010 Nov;66(11):1109-17
Authors: Jovanović N, Božina N, Lovrić M, Medved V, Jakovljević M, Peleš AM
To evaluate the role of cytochrome 450 2D6 (CYP2D6) and ABCB1 variants on plasma risperidone concentrations and treatment response in 83 drug-naive patients experiencing a first episode of psychosis.
Demonstrating utility of pharmacogenetics in pediatric populations: methodological considerations.
Clin Pharmacol Ther. 2010 Dec;88(6):757-9
Authors: Carleton B
Interpretable and meaningful pharmacogenetic data are dependent on accurate characterization of phenotypes. High-quality reports are critical, and important clinical data must not be omitted.
Implications of pharmacogenomics for anesthesia providers.
AANA J. 2010 Oct;78(5):393-9
Authors: Ama T, Bounmythavong S, Blaze J, Weismann M, Marienau MS, Nicholson WT
The practice of anesthesia has long been considered an art and a science, with interpatient variability in drug response being the rule, rather than the exception.
Developing pharmacogenetic evidence throughout clinical development.
Clin Pharmacol Ther. 2010 Dec;88(6):867-70
Authors: Burns DK
Genetics as a discipline is fundamental for the pharmaceutical industry; it contributes to all therapeutic areas and has an impact throughout the research and development continuum, right up to and including clinical practice.